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Adhere to the Instructions on the prescription label and browse all medication guides. Under no circumstances use this medication in larger sized quantities, or for for a longer period than prescribed. Take this medication only until your signs and symptoms obvious up.
Promethazine hydrochloride takes place to be a white to faint yellow, almost odorless, crystalline powder which slowly oxidizes and turns blue on extended exposure to air.
To cut back the chance of dizziness and lightheadedness, rise up slowly and gradually when increasing from a sitting or lying placement.
Codeine creates peripheral vasodilation which can lead to orthostatic hypotension or syncope. Manifestations of histamine release and/or peripheral vasodilation may possibly incorporate pruritus, flushing, crimson eyes and perspiring and/or orthostatic hypotension.
Notify your physician If you're Expecting or Imagine you could be pregnant. All through pregnancy, this merchandise is not encouraged. It may well damage an unborn infant. Check with your health practitioner concerning the threats and advantages of this medication. See also Warning portion.
A possibly lethal symptom sophisticated at times known as Neuroleptic Malignant Syndrome (NMS) has long been documented in Affiliation with promethazine HCl by itself or together with antipsychotic medicine.
An increased possibility of certain malformations with codeine publicity including respiratory malformations, spina bifida and congenital coronary heart defects were described in a few experiments.
Promethazine really should be employed cautiously in folks with cardiovascular disease or with impairment of liver operate.
Codeine Codeine is really an opioid agonist comparatively selective for the mu-opioid receptor, but with a A great deal weaker affinity than morphine. The analgesic and antitussive properties of codeine are actually speculated to come from its conversion to morphine.
Discontinuation of a concomitantly used cytochrome P450 2D6 inhibitor may possibly cause a lessen in codeine plasma concentration and an increase in Energetic metabolite morphine plasma concentration which could boost or extend adverse reactions and could bring about most likely deadly respiratory melancholy.
In Females with typical codeine metabolism (standard CYP2D6 action), the amount of codeine secreted into human milk is small and dose-dependent. There is absolutely no info on the results on the codeine on milk generation.
When the response to an opioid antagonist is suboptimal or only short in mother nature, administer further antagonist as directed via the product or service’s click here prescribing information. The respiratory depressant outcomes of promethazine usually are not reversed by opioid antagonists, like naloxone.
Prior to taking this medication, tell your physician or pharmacist If you're allergic to any of its components; or to opioid discomfort relievers (like morphine); or When you have every other allergies.